Bioinformatics Specialist I - Brown Lab
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About the Lab
The Brown Laboratory studies how the tissue microenvironment and microbiota shape immune development using state-of-the-art single-cell genomics and computational approaches to dissect immune cell heterogeneity and differentiation.
Recent work from the lab defined the cell types and mechanisms that instruct peripheral regulatory T cell development and tolerance to the gut microbiota (https://www.nature.com/articles/s41586-022-05309-5) and identified their ontogeny and developmental trajectories (https://www.nature.com/articles/s41586-026-10198-z). The lab’s work transitions between mechanistic studies in experimental models and translational human immunology studies, with clinical collaborations at Memorial Sloan Kettering Cancer Center (MSK) and the Hospital for Special Surgery.
The Brown Lab is located in the state-of-the-art Zuckerman Research Center in the heart of the Upper East Side in New York City. The ZRC is embedded within the Tri-Institutional Campus, encompassing Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, and Rockefeller University. This environment offers a highly collaborative and intellectually vibrant scientific community with frequent opportunities for networking and career development.
Dr. Chrysothemis Brown is an Assistant Member at MSK, Assistant Professor at the Weill Cornell Graduate School of Medical Sciences, and HHMI Freeman Hrabowski Scholar. She is the recipient of the NIH/NIAID DP2 New Innovator Award, the Josie Robertson Investigator Award, and the V Foundation Pediatric Scholar Award.
For more information about the lab, please visit: www.thebrownlaboratory.com
About the Role
The Brown Laboratory is seeking a highly motivated and detail-oriented Bioinformatics Specialist to support computational analysis of large-scale biological datasets. This role will focus on the analysis of single-cell genomic and spatial transcriptomic datasets to advance the lab’s research on immune cell development and function.
The successful candidate will work closely with a collaborative team of scientists and trainees, helping to design and implement computational workflows that support both fundamental and translational immunology research.
Application Instructions
Please include the following when applying:
Cover letter indicating current and future research interests
CV (including list of publications and technical skills)
Names and contact information for at least two references
What We Provide
A competitive compensation package with comprehensive health and welfare benefits
The opportunity to join the vibrant Tri-Institutional scientific community spanning MSK, Weill Cornell, and Rockefeller University
Exposure to cutting-edge immunology and genomic research
Opportunities for mentorship, career development, and professional growth
Opportunities to contribute to publications and present work at conference
What You’ll Do
Work collaboratively with research scientists to design and implement computational workflows for analyzing large-scale biological datasets
Perform quality control on raw experimental data and preprocess data for downstream analyses
Analyze and interpret high-throughput sequencing data using bioinformatics tools and software, including:
single-cell RNA-seq
scATAC-seq
CUT&Tag
spatial transcriptomics platforms such as 10X Xenium and Visium HD
Apply statistical methods and machine learning approaches to identify patterns and relationships in complex biological datasets
Summarize and communicate analytical findings clearly to research team members
What You Bring
Bachelor’s or Master’s degree in Bioinformatics, Computational Biology, or a related quantitative field
Strong programming skills in Python and R
Experience analyzing genomic or transcriptomic datasets
Experience with commonly used bioinformatics tools and databases
Strong analytical and problem-solving abilities
Excellent communication and collaboration skills
Ability to work effectively within an interdisciplinary research team
Physical Requirements:
Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).
Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.
Please Note:
This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.
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Compensation and Benefits
Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.
Compensation Range
$104,995.00 (minimum) - $131,300.00 (midpoint) - $170,660.00 (maximum)Pay Type:
AnnualHHMI’s salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal consistency when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range.
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