Director/Senior Director, Clinical Business Operations

Waltham, MA April 15, 2026 Full Time

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-state pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit www.crescentbiopharma.com and follow the Company on LinkedIn and X.

We are seeking a Director/Senior Director of Clinical Business Operations is a strategic, hands-on leader responsible for enabling efficient execution of Crescent’s oncology clinical programs through best-in-class vendor strategy, rigorous financial management, and scalable operational processes.

Operating within a lean biotech model, it is critical to ensuring the organization effectively leverages external partners (e.g., CROs, central labs, biomarker vendors) while maintaining strong internal oversight and control. You will partner cross-functionally to support the advancement of a growing oncology pipeline.

Please note:

Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status.

Crescent does not accept unsolicited resumes from external agencies or recruiters. Submission of a resume without a prior written agreement does not create any express or implied contract between Crescent and the agency. Crescent will not pay any fees related to unsolicited resumes.

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Responsibilities

Vendor Strategy & Outsourcing Model

Lead end-to-end vendor strategy and selection across all clinical development functions, with a focus on oncology-specific vendors

Design and implement a fit-for-purpose outsourcing model aligned to:

Ensure vendor scopes reflect oncology trial complexity

Establish clear governance, KPIs, and escalation pathways while maintaining lean internal oversight

Clinical Financial Management Across Portfolio

Own end-to-end financial oversight for all Crescent clinical trials

Develop and manage study budgets that reflect oncology-specific cost drivers

Provide real-time financial visibility and proactive insights to Clinical Development leadership

Identify cost efficiencies while ensuring quality and speed are not compromised

Portfolio Forecasting & Scenario Planning

Lead integrated financial forecasting across multiple oncology programs and phases

Incorporate key development assumptions into forecasts

Drive scenario planning to support portfolio prioritization and investment decisions in collaboration with functional area representatives

Partner closely with Finance to align on long range planning and budgeting for CMO Organization

Vendor Change Order Governance

Establish and lead a disciplined change order management process in a high-change oncology environment

Critically review and negotiate change orders in partnership with vendor functional owners

Ensure alignment between scope, timelines, and cost, preventing budget creep

Maintain transparency of financial impact across programs

Clinical Development Materials & Decision Support

Lead creation of high-impact materials for Development Org for governance and executive forum

Synthesize complex operational and financial data into clear, decision-ready insights

Enable leadership to make data-driven trade-offs across programs and timelines

Process Optimization in a Lean Environment

Identify and implement scalable processes that enable efficient trial execution without adding unnecessary infrastructure

Standardize key workflows across programs (e.g., budgeting, forecasting, vendor oversight)

Drive efficiencies in:

Study startup timelines

Vendor onboarding and management

Cross-functional coordination

Continuously assess where to build vs. outsource capabilities

Education & Experience

Bachelor’s degree required; advanced degree (MBA, MS, or equivalent) preferred

~10–15+ years (Director) / 15+ years (Senior Director) of experience in biotech/pharma

Demonstrated expertise in clinical trial financial management and forecasting and vendor selection and CRO oversight in early phase clinical trials

Deep understanding of complex clinical trial designs in Oncology or Rare Disease

Proven ability to balance strategic leadership with hands-on execution

Strong business acumen and financial rigor

Strategic outsourcing and vendor management expertise

Ability to influence without authority in a matrixed environment

Operational agility and problem-solving in fast-paced settings

Clear, concise communication of complex information

Salary Range

The salary range for this position is $X to $X. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography.

Additional Description for Pay Transparency:

The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s savings plan (401(k)). This position is eligible to participate in the Company’s long-term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation – Unlimited PTO; Sick time – 10 days per calendar year; Holiday pay, including two Company shut downs; Parental Leave – 16 weeks within one year of the birth/adoption/foster care of a child; FMLA; Military Leave. Additional information can be found - https://www.crescentbiopharma.com/careers/#benefits