Director, Translational Medicine

Waltham, MA April 8, 2026 Full Time

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit www.crescentbiopharma.com and follow the Company on LinkedIn and X.

We are seeking a Director of Translational Medicine to join our team. You will provide scientific and strategic leadership for one or more programs supporting the advancement of Crescent ‘s pipeline focusing on next generation immuno-oncology (I/O) and antibody-drug conjugate (ADC). Working with cross-functional teams, you will develop and execute the Translational Medicine strategy to help shape the clinical development plans and contribute to clinical and scientific deliverables.

Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status.

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Responsibilities

Develop and execute translational strategy to help advance Crescent’s clinical pipeline

Provide oversight of the development, validation, and execution of fit-for-purpose clinical biomarker assays with external CROs and actively manage vendor relationships

Drive clinical biomarker sample testing and data delivery in close collaboration with clinical development operations team

Lead biomarker data analysis and contribute to clinical and scientific data deliverables

Serve as the translational medicine lead in cross-functional program teams and support integrated program development plans

Author translational medicine sections in IND modules, clinical protocols, IBs, ICFs, and other clinical documents and technical reports, and respond to regulatory inquiries related to translational medicine

Provide translational input into novel target identification

Education & Experience

PhD/MD in Cancer Biology, Immuno-Oncology, Immunology, Molecular Biology, Pathology, or other scientifically related field required
Minimum 8 years of industry experience in translational medicine and clinical biomarkers
Experience in leading translational efforts to advance the IO and/or ADC programs from IND-enabling phase through early phase clinical development and/or from early phase clinical development through late phase
Prior experience in CDx development is a plus
Strong team player with the ability to work in cross-functional matrix
Excellent interpersonal, verbal, and written communication skills

What We Offer

Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment

Competitive compensation, including base salary, performance bonus, and equity

100% employer-paid benefits package

Flexible PTO; also, two, one-week company-wide shutdowns each year

A commitment to your professional development, with access to resources, mentorship, and growth opportunities